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The theory and practice for observing design layout of Southwest China vortex atmospheric scientific experiment

Li Yueqing,Xu Xiangde,Zhao Xingbing

Strategic Study of CAE 2012, Volume 14, Issue 9,   Pages 35-45

Abstract: research and field experiment on Southwest China vortex, this paper gives out the importance of the observationalbasis with Southwest China vortex atmospheric scientific experiment for the basic data, scientific researchatmospheric scientific experiment from the aspects of the network distribution, equipment level and observational

Keywords： Southwest China vortex     scientific experiment     observational basis     design-layout technology    

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Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

Jian Liu, Weiming Wang

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 333-339 doi: 10.1007/s11684-017-0564-1

Abstract:

Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.

Keywords： nephrotic syndrome     focal segmental glomerulosclerosis     genetic    

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Core designing of a new type of TVS-2M FAs: neutronics and thermal-hydraulics design basis limits

Saeed GHAEMI, Farshad FAGHIHI

Frontiers in Energy 2021, Volume 15, Issue 1,   Pages 256-278 doi: 10.1007/s11708-018-0583-x

Abstract: One of the most important aims of this study is to improve the core of the current VVER reactors to achieve more burn-up (or more cycle length) and more intrinsic safety. It is an independent study on the Russian new proposed FAs, called TVS-2M, which would be applied for the future advanced VVERs. Some important aspects of neutronics as well as thermal hydraulics investigations (and analysis) of the new type of Fas are conducted, and results are compared with the standards PWR CDBL. The TVS-2M FA contains gadolinium-oxide which is mixed with UO (for different Gd densities and U-235 enrichments which are given herein), but the core does not contain BARs. The new type TVS-2M Fas are modeled by the SARCS software package to find the PMAXS format for three states of CZP and HZP as well as HFP, and then the whole core is simulated by the PARCS code to investigate transient conditions. In addition, the WIMS-D5 code is suggested for steady core modeling including TVS-2M FAs and/or TVS FAs. Many neutronics aspects such as the first cycle length (first cycle burn up in terms of MW d/kgU), the critical concentration of boric acid at the BOC as well as the cycle length, the axial, and radial power peaking factors, differential and integral worthy of the most reactive CPS-CRs, reactivity coefficients of the fuel, moderator, boric acid, and the under-moderation estimation of the core are conducted and benchmarked with the PWR CDBL. Specifically, the burn-up calculations indicate that the 45.6 d increase of the first cycle length (which corresponds to 1.18 MW d/kgU increase of burn-up) is the best improving aim of the new FA type called TVS-2M. Moreover, thermal-hydraulics core design criteria such as MDNBR (based on W3 correlation) and the maximum of fuel and clad temperatures (radially and axially), are investigated, and discussed based on the CDBL.

Keywords： TVS-2M FAs     core design basis limits     VVER-1000     analysis     mixture of uranium-gadolinium oxides fuels     thermal-hydraulics    

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Developing effective tumor vaccines: basis, challenges and perspectives

XU Qingwen, CHEN Weifeng

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 11-19 doi: 10.1007/s11684-007-0003-9

Abstract: A remarkable advance in tumor immunology during the last decade is the elucidation of the antigenic basis

Keywords： development     conventional     identification     elucidation     Successful immunotherapy    

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Predictive Analysis and Observational Construction for aLarge-Scale Underground Powerhouse Cavern Complex

Wang Yisen,Liu Sihong

Strategic Study of CAE 2007, Volume 9, Issue 3,   Pages 35-40

Abstract:

In this paper, the predictive analysis and observational construction

Keywords： underground cavern complex     predictive analysis     observational construction     rock supportdesign    

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Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 651-658 doi: 10.1007/s11684-021-0859-0

Abstract: To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifested primarily as throat discomfort, we conducted a multicentric and retrospective study in the cardiology and otorhinolaryngology departments. Records of patients with primary complaint of throat discomfort, absence of chest pain at onset, and an ultimate diagnosis of acute coronary syndrome, as well as patients with pharyngitis (as controls) were collected from May 2015 to April 2016. The patients’ main manifestations were compared. Logistic regression results showed that chest tightness, dyspnea, perspiring, and exertional throat symptoms were significantly associated with acute coronary syndrome, with odds ratios of 8.3 (95% CI 2.2−31.5), 10.9 (95% CI 1.8−66.9), 25.4 (95% CI 3.6−179.9), and 81.2 (95% CI 13.0−506.7). A total of 25 (56.82%) out of 44 acute coronary syndrome patients, who were first admitted to the otorhinolaryngology department, were misdiagnosed, with a 12% (3/25) mortality rate. Throat discomfort can be the principal manifestation of acute coronary syndrome. Such patients exhibit high misdiagnosis and mortality rates. Exertional throat symptoms, chest tightness, perspiring, and dyspnea were important indicators of acute coronary syndrome in patients whose main complaint was throat discomfort. The awareness of this condition will result in prompt diagnosis and reduce morbidity and mortality.

Keywords： acute coronary syndrome (ACS)     throat discomfort (TD)     throat pain     cardiology departments     non-cardiologic physicians    

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Leakage location system for oil pipeline on basis of stress wave detection

WANG Bangfeng, CHEN Renwen

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3,   Pages 307-312 doi: 10.1007/s11465-008-0047-9

Abstract: An online monitoring system was developed for rapidly determining the exact location of the holing position in an oil pipeline by monitoring and analyzing the characteristics of the strain wave caused by the hole. The system has a master-slaver computer structure based on a remote wireless network. The master system takes charge of managing and controlling the whole system, identifying the holing stress wave, and calculating the holing position. The slaver system is responsible for sampling the strain wave signal from the pipeline. The characteristics of the strain wave signal are extracted by a Hilbert-Huang transform based on a signal processing approach. The exact holing position can be obtained by a time delay locating method with stress wave characteristics. The experimental results of the in-service pipeline show that the average locating error of the system is less than 10 m, the accuracy ratio for the holing alarm is more than 90%, and the time that the system takes to respond to the leakage is less than 10 s.
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Current situation and challenge of registry in China

Yang Zhang,Yuji Feng,Zhi Qu,Yali Qi,Siyan Zhan

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 294-299 doi: 10.1007/s11684-014-0355-x

Abstract: Patient registries for observational studies were retrieved from the International Clinical Trials Registry

Keywords： observational study     Chinese     registry study     patient registries    

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Self-organizing method for collaboration in multi-robot system on basis of balance principle

DONG Yangbin, JIANG Jinping, HE Yan

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3,   Pages 283-287 doi: 10.1007/s11465-008-0044-z

Abstract: Furthermore, an algorithm is designed for adjusting subtask selection on the basis of this principle.

Keywords： algorithm     self-organizing principle     validity     Simulation     allocation    

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Clustering economic sectors in China on a life cycle basis to achieve environmental sustainability

Sai LIANG, Tianzhu ZHANG, Xiaoping JIA

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1,   Pages 97-108 doi: 10.1007/s11783-012-0402-2

Abstract: analysis, this study clusters China’s economic sectors and determines their priority on a life cycle basis

Keywords： cluster analysis     input-output model     life cycle     material flow analysis     sustainable development    

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Explicit optimization method for cutting-screw-thread on the basis of dual-RSM

Zhengbao LEI, Shubin WEI, Qingyun DU

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4,   Pages 423-430 doi: 10.1007/s11465-010-0109-7

Abstract: To obtain the explicit function for optimizing the cutting-screw-thread (CST) in crash, the simulations of frontal crash at the speed of 56 km/h have been carried out in VPG. The peak acceleration in crash has been taken as the evaluation index of energy absorption characteristics. First, the single factor experiment was taken based on six parameters affecting on the absorption characteristics of CST. Second, the peak acceleration function of each parameter by using response surface method (RSM) is obtained. Third, the explicit resultant peak acceleration function of six parameters by using RSM again is obtained. A dual RSM-based explicit method is proposed. According to this function, the best size dimensions of CST in different crash conditions could be easily obtained. Finally, an example shows that the values of the calculation errors for simulation value and target value (40 g) are 3.6% and 1.3%, respectively. This method can satisfy the demand for engineering accuracy.

Keywords： vehicle engineering     crash     safety     explicit method     response surface method    

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Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4,   Pages 399-406 doi: 10.1007/s11705-009-0253-y

Abstract: -Carrageenan and -lactoglobulin (-lg) stabilized oil-in-water (O/W) emulsions, which can be used for the oral administration of bioactive but environmentally sensitive ingredients, have been successfully prepared. The effects of protein/polysaccharide ratios, total biopolymer concentration, environmental stress (thermal processing and sonication), and pH on the complex formation between -carrageenan and -lactoglobulin have been investigated. We found that -lactoglobulin and-carrageenan stabilized emulsions can be formed at pH values of 6.0, 4.0, and 3.4. However, the microstructures of emulsions stabilized by -lactoglobulin and -carrageenan was identified by optical microscopy, and it indicated that the emulsion prepared at pH 6.0 flocculated more extensively, while its hydrodynamic radius was much bigger than those prepared at pH 4.0 and 3.4. Regarding rheological properties, the emulsion of pH 6.0 showed a more solid-like behavior but with a lower viscosity than those of pH 4.0 and 3.4. The optimum concentration ranges for -lg and-carrageenan to form stable emulsions at pH 4.0 and 3.4 were 0.3wt-%―0.6wt-% and 0.4wt-%―0.7wt-%, respectively.
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Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”

Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0916-8

Abstract: · No preference is set between CA and IA models to assess toxicity of metal mixtures. · Increased model complexity does not, by itself, lead to improved performance. · Not all significant deviations have biological meaning due to poor reproducibility. · Interactions are suggested to incorporate when they are significant and repeated. Observed effects of metal mixtures on animals and plants often differ from the estimates, which are commonly calculated by adding up the biological responses of individual metals. This difference from additivity is commonly referred to as being a consequence of specific interactions between metals. The science of how to quantify metal interactions and whether to include them in risk assessment models is in its infancy. This review summarizes the existing predictive tools for evaluating the combined toxicity of metals present in mixtures and indicates the advantages and disadvantages of each method. We intend to provide eco-toxicologists with background information on how to make good use of the tools and how to advance the methods for assessing toxicity of metal mixtures. It is concluded that statistically significant deviations from additivity are not necessarily biologically relevant. Incorporation of interactions between metals in a model does not on forehand mean that the model is more accurate than a model developed based on additivity only. It is recommended to first use a relatively simple method for effect prediction of uninvestigated metal mixtures. To improve the reliability of toxicity modeling for metal mixtures, further efforts should focus on balancing the relationship between the significance of statistics and the biological meaning, and unraveling the toxicity mechanisms of metals and their mixtures.

Keywords： Metal     Mixtures     Toxicity     Additivity     Modeling     Interactions    

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An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 362-367 doi: 10.1007/s11684-014-0363-x

Abstract:

This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013 was collected. Changes in the indexes of CD4 counts (≤200, 201–350, 351–500 and>500 cells/mm3) at five time points (0, 12, 36, 60 and 84 months) and different treatments [TCM and TCM plus antiretroviral therapy (ART)] were compared. Repeated measures test indicated no interaction between group and time (P>0.05). Degrees of increasing and decreasing CD4 count of the two groups at four different frames were statistically significant compared with the baseline. The CD4 count between the two groups was not statistically significant. For CD4 count of≤200 cells/mm3, the mean CD4 count changes were 21 and 28 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 201–350 cells/mm3, the mean CD4 count changes were 6 and 25 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 351–500 cells/mm3, the mean CD4 count changes were -13 and -7 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of>500 cells/mm3, the mean CD4 count changes were -34 and -17 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS, and may achieve lasting effectiveness.

Keywords： AIDS     HIV     CD4     traditional Chinese medicine     linear models    

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Transcriptomic basis of neutrophil ratio variation induced by poly I:C stimulation in porcine peripheral

Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 342-352 doi: 10.15302/J-FASE-2017162

Abstract: The study provides a basic understanding of the molecular basis for the antiviral capacity of pigs and

Keywords： neutrophil     peripheral blood     pig     poly I:C     transcriptome    

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Title Author Date Type Operation

The theory and practice for observing design layout of Southwest China vortex atmospheric scientific experiment

Li Yueqing,Xu Xiangde,Zhao Xingbing

Journal Article

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

Jian Liu, Weiming Wang

Journal Article

Core designing of a new type of TVS-2M FAs: neutronics and thermal-hydraulics design basis limits

Saeed GHAEMI, Farshad FAGHIHI

Journal Article

Developing effective tumor vaccines: basis, challenges and perspectives

XU Qingwen, CHEN Weifeng

Journal Article

Predictive Analysis and Observational Construction for aLarge-Scale Underground Powerhouse Cavern Complex

Wang Yisen,Liu Sihong

Journal Article

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Journal Article

Leakage location system for oil pipeline on basis of stress wave detection

WANG Bangfeng, CHEN Renwen

Journal Article

Current situation and challenge of registry in China

Yang Zhang,Yuji Feng,Zhi Qu,Yali Qi,Siyan Zhan

Journal Article

Self-organizing method for collaboration in multi-robot system on basis of balance principle

DONG Yangbin, JIANG Jinping, HE Yan

Journal Article

Clustering economic sectors in China on a life cycle basis to achieve environmental sustainability

Sai LIANG, Tianzhu ZHANG, Xiaoping JIA

Journal Article

Explicit optimization method for cutting-screw-thread on the basis of dual-RSM

Zhengbao LEI, Shubin WEI, Qingyun DU

Journal Article

Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

Journal Article

Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”

Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg

Journal Article

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

Jian Wang,Biyan Liang,Xiaoping Zhang,Liran Xu,Xin Deng,Xiuhui Li,Lu Fang,Xinghua Tan,Yuxiang Mao,Guoliang Zhang,Yuguang Wang

Journal Article

Transcriptomic basis of neutrophil ratio variation induced by poly I:C stimulation in porcine peripheral

Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI

Journal Article